| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | CAR | 26-10 | W | 4.5 | 45.5 | TIAA Bank Stadium |
| 2025-09-14 | 2 | @ | CIN | 27-31 | L | 3.5 | 49.5 | Paycor Stadium |
| 2025-09-21 | 3 | vs | HOU | 17-10 | W | 1.5 | 43.5 | TIAA Bank Stadium |
| 2025-09-28 | 4 | @ | SF | 26-21 | W | 3.5 | 45.5 | Levi's Stadium |
| 2025-10-06 | 5 | vs | KC | 31-28 | W | -3.5 | 45.5 | TIAA Bank Stadium |
| 2025-10-12 | 6 | vs | SEA | 12-20 | L | -1.5 | 47.5 | TIAA Bank Stadium |
| 2025-10-19 | 7 | vs | LA | 7-35 | L | -3 | 44.5 | TIAA Bank Stadium |
| 2025-11-02 | 9 | @ | LV | 30-29 | W | -2.5 | 43.5 | Allegiant Stadium |
| 2025-11-09 | 10 | @ | HOU | 29-36 | L | -1.5 | 37.5 | NRG Stadium |
| 2025-11-16 | 11 | vs | LAC | 35-6 | W | -3 | 43.5 | TIAA Bank Stadium |
| 2025-11-23 | 12 | @ | ARI | 27-24 | W | -2.5 | 47.5 | State Farm Stadium |
| 2025-11-30 | 13 | @ | TEN | 25-3 | W | -6 | 42.5 | Nissan Stadium |
| 2025-12-07 | 14 | vs | IND | 36-19 | W | -2.5 | 44.5 | TIAA Bank Stadium |
| 2025-12-14 | 15 | vs | NYJ | 48-20 | W | 13.5 | 40.5 | TIAA Bank Stadium |
| 2025-12-21 | 16 | @ | DEN | 34-20 | W | 3.5 | 46.5 | Empower Field at Mile High |
| 2025-12-28 | 17 | @ | IND | 23-17 | W | -3.5 | 48.5 | Lucas Oil Stadium |
| 2026-01-04 | 18 | vs | TEN | 41-7 | W | 12.5 | 46.5 | TIAA Bank Stadium |
| 2026-01-11 | 19 | vs | BUF | 24-27 | L | 1.5 | 51.5 | TIAA Bank Stadium |
