| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | LA | 9-14 | L | 3.5 | 43.5 | SoFi Stadium |
| 2025-09-15 | 2 | vs | TB | 19-20 | L | 2.5 | 42.5 | NRG Stadium |
| 2025-09-21 | 3 | @ | JAX | 10-17 | L | 1.5 | 43.5 | TIAA Bank Stadium |
| 2025-09-28 | 4 | vs | TEN | 26-0 | W | 7.5 | 39.5 | NRG Stadium |
| 2025-10-05 | 5 | @ | BAL | 44-10 | W | -2.5 | 41.5 | M&T Bank Stadium |
| 2025-10-20 | 7 | @ | SEA | 19-27 | L | 3 | 41.5 | Lumen Field |
| 2025-10-26 | 8 | vs | SF | 26-15 | W | 2.5 | 41.5 | NRG Stadium |
| 2025-11-02 | 9 | vs | DEN | 15-18 | L | 1.5 | 40.5 | NRG Stadium |
| 2025-11-09 | 10 | vs | JAX | 36-29 | W | -1.5 | 37.5 | NRG Stadium |
| 2025-11-16 | 11 | @ | TEN | 16-13 | W | -5.5 | 37.5 | Nissan Stadium |
| 2025-11-20 | 12 | vs | BUF | 23-19 | W | -5.5 | 43.5 | NRG Stadium |
| 2025-11-30 | 13 | @ | IND | 20-16 | W | 3 | 44.5 | Lucas Oil Stadium |
| 2025-12-07 | 14 | @ | KC | 20-10 | W | 4.5 | 41.5 | GEHA Field at Arrowhead Stadium |
| 2025-12-14 | 15 | vs | ARI | 40-20 | W | 10.5 | 42.5 | NRG Stadium |
| 2025-12-21 | 16 | vs | LV | 23-21 | W | 14.5 | 39.5 | NRG Stadium |
| 2025-12-27 | 17 | @ | LAC | 20-16 | W | 1.5 | 40.5 | SoFi Stadium |
| 2026-01-04 | 18 | vs | IND | 38-30 | W | 9.5 | 37.5 | NRG Stadium |
| 2026-01-12 | 19 | @ | PIT | 30-6 | W | -3 | 38.5 | Acrisure Stadium |
| 2026-01-18 | 20 | @ | NE | 16-28 | L | 3 | 40.5 | Gillette Stadium |
