| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | DET | 27-13 | W | 1.5 | 48.5 | Lambeau Field |
| 2025-09-11 | 2 | vs | WAS | 27-18 | W | 3.5 | 48.5 | Lambeau Field |
| 2025-09-21 | 3 | @ | CLE | 10-13 | L | -8.5 | 41.5 | FirstEnergy Stadium |
| 2025-09-28 | 4 | @ | DAL | 40-40 | T | -7 | 47.5 | AT&T Stadium |
| 2025-10-12 | 6 | vs | CIN | 27-18 | W | 14 | 44.5 | Lambeau Field |
| 2025-10-19 | 7 | @ | ARI | 27-23 | W | -7 | 44.5 | State Farm Stadium |
| 2025-10-26 | 8 | @ | PIT | 35-25 | W | -3 | 46.5 | Acrisure Stadium |
| 2025-11-02 | 9 | vs | CAR | 13-16 | L | 12.5 | 43.5 | Lambeau Field |
| 2025-11-10 | 10 | vs | PHI | 7-10 | L | 1.5 | 45.5 | Lambeau Field |
| 2025-11-16 | 11 | @ | NYG | 27-20 | W | -7.5 | 41.5 | MetLife Stadium |
| 2025-11-23 | 12 | vs | MIN | 23-6 | W | 6.5 | 41.5 | Lambeau Field |
| 2025-11-27 | 13 | @ | DET | 31-24 | W | 2.5 | 48.5 | Ford Field |
| 2025-12-07 | 14 | vs | CHI | 28-21 | W | 6.5 | 44.5 | Lambeau Field |
| 2025-12-14 | 15 | @ | DEN | 26-34 | L | -1.5 | 42.5 | Empower Field at Mile High |
| 2025-12-20 | 16 | @ | CHI | 16-22 | L | 1.5 | 45.5 | Soldier Field |
| 2025-12-27 | 17 | vs | BAL | 24-41 | L | 2.5 | 38.5 | Lambeau Field |
| 2026-01-04 | 18 | @ | MIN | 3-16 | L | 12.5 | 37.5 | U.S. Bank Stadium |
| 2026-01-10 | 19 | @ | CHI | 27-31 | L | -2.5 | 45.5 | Soldier Field |
