| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | GB | 13-27 | L | 1.5 | 48.5 | Lambeau Field |
| 2025-09-14 | 2 | vs | CHI | 52-21 | W | 6 | 46.5 | Ford Field |
| 2025-09-22 | 3 | @ | BAL | 38-30 | W | 4.5 | 53.5 | M&T Bank Stadium |
| 2025-09-28 | 4 | vs | CLE | 34-10 | W | 10 | 44.5 | Ford Field |
| 2025-10-05 | 5 | @ | CIN | 37-24 | W | -10.5 | 49.5 | Paycor Stadium |
| 2025-10-12 | 6 | @ | KC | 17-30 | L | 2.5 | 51.5 | GEHA Field at Arrowhead Stadium |
| 2025-10-20 | 7 | vs | TB | 24-9 | W | 6 | 54.5 | Ford Field |
| 2025-11-02 | 9 | vs | MIN | 24-27 | L | 9.5 | 47.5 | Ford Field |
| 2025-11-09 | 10 | @ | WAS | 44-22 | W | -8.5 | 49.5 | FedExField |
| 2025-11-16 | 11 | @ | PHI | 9-16 | L | 2.5 | 46.5 | Lincoln Financial Field |
| 2025-11-23 | 12 | vs | NYG | 34-27 | W | 14 | 50.5 | Ford Field |
| 2025-11-27 | 13 | vs | GB | 24-31 | L | 2.5 | 48.5 | Ford Field |
| 2025-12-04 | 14 | vs | DAL | 44-30 | W | 3.5 | 55.5 | Ford Field |
| 2025-12-14 | 15 | @ | LA | 34-41 | L | 5.5 | 54.5 | SoFi Stadium |
| 2025-12-21 | 16 | vs | PIT | 24-29 | L | 7.5 | 52.5 | Ford Field |
| 2025-12-25 | 17 | @ | MIN | 10-23 | L | -7 | 45.5 | U.S. Bank Stadium |
| 2026-01-04 | 18 | @ | CHI | 19-16 | W | 3.5 | 51.5 | Soldier Field |
