| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | CIN | 16-17 | L | -5.5 | 47.5 | FirstEnergy Stadium |
| 2025-09-14 | 2 | @ | BAL | 17-41 | L | 12.5 | 46.5 | M&T Bank Stadium |
| 2025-09-21 | 3 | vs | GB | 13-10 | W | -8.5 | 41.5 | FirstEnergy Stadium |
| 2025-09-28 | 4 | @ | DET | 10-34 | L | 10 | 44.5 | Ford Field |
| 2025-10-05 | 5 | vs | MIN | 17-21 | L | -3.5 | 35.5 | FirstEnergy Stadium |
| 2025-10-12 | 6 | @ | PIT | 9-23 | L | 5.5 | 37.5 | Acrisure Stadium |
| 2025-10-19 | 7 | vs | MIA | 31-6 | W | 2.5 | 34.5 | FirstEnergy Stadium |
| 2025-10-26 | 8 | @ | NE | 13-32 | L | 7 | 40.5 | Gillette Stadium |
| 2025-11-09 | 10 | @ | NYJ | 20-27 | L | -1.5 | 37.5 | MetLife Stadium |
| 2025-11-16 | 11 | vs | BAL | 16-23 | L | -7.5 | 37.5 | FirstEnergy Stadium |
| 2025-11-23 | 12 | @ | LV | 24-10 | W | 3 | 35.5 | Allegiant Stadium |
| 2025-11-30 | 13 | vs | SF | 8-26 | L | -5.5 | 35.5 | FirstEnergy Stadium |
| 2025-12-07 | 14 | vs | TEN | 29-31 | L | 4.5 | 33.5 | FirstEnergy Stadium |
| 2025-12-14 | 15 | @ | CHI | 3-31 | L | 7.5 | 38.5 | Soldier Field |
| 2025-12-21 | 16 | vs | BUF | 20-23 | L | -10.5 | 41.5 | FirstEnergy Stadium |
| 2025-12-28 | 17 | vs | PIT | 13-6 | W | -4.5 | 35.5 | FirstEnergy Stadium |
| 2026-01-04 | 18 | @ | CIN | 20-18 | W | 9.5 | 47.5 | Paycor Stadium |
