| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-08 | 1 | vs | MIN | 24-27 | L | -1.5 | 43.5 | Soldier Field |
| 2025-09-14 | 2 | @ | DET | 21-52 | L | 6 | 46.5 | Ford Field |
| 2025-09-21 | 3 | vs | DAL | 31-14 | W | -1.5 | 49.5 | Soldier Field |
| 2025-09-28 | 4 | @ | LV | 25-24 | W | 1.5 | 47.5 | Allegiant Stadium |
| 2025-10-13 | 6 | @ | WAS | 25-24 | W | 5.5 | 49.5 | FedExField |
| 2025-10-19 | 7 | vs | NO | 26-14 | W | 4.5 | 43.5 | Soldier Field |
| 2025-10-26 | 8 | @ | BAL | 16-30 | L | 2.5 | 45.5 | M&T Bank Stadium |
| 2025-11-02 | 9 | @ | CIN | 47-42 | W | -3 | 51.5 | Paycor Stadium |
| 2025-11-09 | 10 | vs | NYG | 24-20 | W | 4.5 | 45.5 | Soldier Field |
| 2025-11-16 | 11 | @ | MIN | 19-17 | W | 3 | 47.5 | U.S. Bank Stadium |
| 2025-11-23 | 12 | vs | PIT | 31-28 | W | 3 | 46.5 | Soldier Field |
| 2025-11-28 | 13 | @ | PHI | 24-15 | W | 7 | 43.5 | Lincoln Financial Field |
| 2025-12-07 | 14 | @ | GB | 21-28 | L | 6.5 | 44.5 | Lambeau Field |
| 2025-12-14 | 15 | vs | CLE | 31-3 | W | 7.5 | 38.5 | Soldier Field |
| 2025-12-20 | 16 | vs | GB | 22-16 | W | 1.5 | 45.5 | Soldier Field |
| 2025-12-28 | 17 | @ | SF | 38-42 | L | 3.5 | 51.5 | Levi's Stadium |
| 2026-01-04 | 18 | vs | DET | 16-19 | L | 3.5 | 51.5 | Soldier Field |
| 2026-01-10 | 19 | vs | GB | 31-27 | W | -2.5 | 45.5 | Soldier Field |
| 2026-01-18 | 20 | vs | LA | 17-20 | L | -3.5 | 49.5 | Soldier Field |
