| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | JAX | 10-26 | L | 4.5 | 45.5 | TIAA Bank Stadium |
| 2025-09-14 | 2 | @ | ARI | 22-27 | L | 7 | 45.5 | State Farm Stadium |
| 2025-09-21 | 3 | vs | ATL | 30-0 | W | -5.5 | 44.5 | Bank of America Stadium |
| 2025-09-28 | 4 | @ | NE | 13-42 | L | 5.5 | 42.5 | Gillette Stadium |
| 2025-10-05 | 5 | vs | MIA | 27-24 | W | -1.5 | 44.5 | Bank of America Stadium |
| 2025-10-12 | 6 | vs | DAL | 30-27 | W | -3 | 47.5 | Bank of America Stadium |
| 2025-10-19 | 7 | @ | NYJ | 13-6 | W | 1.5 | 39.5 | MetLife Stadium |
| 2025-10-26 | 8 | vs | BUF | 9-40 | L | -7 | 47.5 | Bank of America Stadium |
| 2025-11-02 | 9 | @ | GB | 16-13 | W | 12.5 | 43.5 | Lambeau Field |
| 2025-11-09 | 10 | vs | NO | 7-17 | L | 5.5 | 38.5 | Bank of America Stadium |
| 2025-11-16 | 11 | @ | ATL | 30-27 | W | 4.5 | 42.5 | Mercedes-Benz Stadium |
| 2025-11-24 | 12 | @ | SF | 9-20 | L | 7.5 | 48.5 | Levi's Stadium |
| 2025-11-30 | 13 | vs | LA | 31-28 | W | -10 | 44.5 | Bank of America Stadium |
| 2025-12-14 | 15 | @ | NO | 17-20 | L | -2.5 | 41.5 | Mercedes-Benz Superdome |
| 2025-12-21 | 16 | vs | TB | 23-20 | W | -3 | 44.5 | Bank of America Stadium |
| 2025-12-28 | 17 | vs | SEA | 10-27 | L | -6.5 | 42.5 | Bank of America Stadium |
| 2026-01-03 | 18 | @ | TB | 14-16 | L | 3 | 43.5 | Raymond James Stadium |
| 2026-01-10 | 19 | vs | LA | 31-34 | L | -10 | 44.5 | Bank of America Stadium |
