| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | BAL | 41-40 | W | -1.5 | 50.5 | New Era Field |
| 2025-09-14 | 2 | @ | NYJ | 30-10 | W | -6 | 47.5 | MetLife Stadium |
| 2025-09-18 | 3 | vs | MIA | 31-21 | W | 12.5 | 50.5 | New Era Field |
| 2025-09-28 | 4 | vs | NO | 31-19 | W | 15.5 | 48.5 | New Era Field |
| 2025-10-05 | 5 | vs | NE | 20-23 | L | 7.5 | 49.5 | New Era Field |
| 2025-10-13 | 6 | @ | ATL | 14-24 | L | -3.5 | 49.5 | Mercedes-Benz Stadium |
| 2025-10-26 | 8 | @ | CAR | 40-9 | W | -7 | 47.5 | Bank of America Stadium |
| 2025-11-02 | 9 | vs | KC | 28-21 | W | -2.5 | 53.5 | New Era Field |
| 2025-11-09 | 10 | @ | MIA | 13-30 | L | -8.5 | 50.5 | Hard Rock Stadium |
| 2025-11-16 | 11 | vs | TB | 44-32 | W | 6 | 46.5 | New Era Field |
| 2025-11-20 | 12 | @ | HOU | 19-23 | L | -5.5 | 43.5 | NRG Stadium |
| 2025-11-30 | 13 | @ | PIT | 26-7 | W | -3 | 44.5 | Acrisure Stadium |
| 2025-12-07 | 14 | vs | CIN | 39-34 | W | 6 | 54.5 | New Era Field |
| 2025-12-14 | 15 | @ | NE | 35-31 | W | -2.5 | 49.5 | Gillette Stadium |
| 2025-12-21 | 16 | @ | CLE | 23-20 | W | -10.5 | 41.5 | FirstEnergy Stadium |
| 2025-12-28 | 17 | vs | PHI | 12-13 | L | 3 | 45.5 | New Era Field |
| 2026-01-04 | 18 | vs | NYJ | 35-8 | W | 12.5 | 39.5 | New Era Field |
| 2026-01-11 | 19 | @ | JAX | 27-24 | W | 1.5 | 51.5 | TIAA Bank Stadium |
| 2026-01-17 | 20 | @ | DEN | 30-33 | L | 1.5 | 45.5 | Empower Field at Mile High |
